We observed variable effects of IFNγ on tumor sensitivity to NK cells that are cell line dependent and attributable to individual MHC-class I and ICAM-1 responses, suggesting that IFNγ effects on cancer cell sensitivity to NK cells should not be broadly generalized, although further experiments with cell lines and patient samples may determine whether specific tumor types have generalizable IFNγ responses. The gene discussed is IFNG; the disease is neoplasm.