Furthermore, P. berghei ANKA peroxiredoxin induces a significant amount of MC-derived TNF secretion from IgE-mediated protection through FcεRI on MCs and innate immunity by means of toll-like receptor (TLR) 4 with myeloid differentiation primary response gene 88 and MD-2 and plays a role in innate and acquired immune responses in malaria (50). Here, TNF is linked to malaria.