SRGN and infection: In both wild-type and serglycin-deficient mice, intraperitoneal infection with T. gondii resulted in highly increased extracellular levels of glycosaminoglycans, including hyaluronan and chondroitin sulfate A, suggesting that serglycin proteoglycan is dispensable for normal secretion and activity of MC proteases in response to T. gondii infection (81).