Of interest, a number of studies demonstrate the role of σ1 receptors in neurological diseases like epilepsy (Rousseaux and Greene, 2015) and overstimulation of σ1 receptors has been associated with GLUT-related excitatory effects (via NMDA receptors) (Borlot et al., 2014; Nicita et al., 2014; Rousseaux and Greene, 2015). This evidence concerns the gene SLC2A1 and nervous system disorder.