TARDBP and neurodegenerative disease: It is responsible for the correct folding of a number of newly synthesized proteins and for the refolding of misfolded proteins associated with neurodegenerative diseases, including TDP-43 (Basso et al., 2009; Daturpalli et al., 2013; Carlomagno et al., 2014; Schirmer et al., 2016).