Several other ALS-linked mutated proteins form intracellular aggregates, including C9ORF72 (DeJesus-Hernandez et al., 2011), transactive response DNA binding protein (TDP-43), fused in sarcoma/translocated in liposarcoma (FUS), vesicle associated protein B (VAPB), ubiquilin-2, optineurin, and protein disulphide isomerase 1 and 3 (PDIA1 and PDIA3) (Robberecht and Philips, 2013). The gene discussed is P4HB; the disease is amyotrophic lateral sclerosis.