The results of half quantitative analysis for protein by Western blot indicated that the relative expression of SphK2 in NSCLC tumor tissues was much higher than in normal tissues (p < 0.001; Fig. 1b), and the relative expression of SphK2 in NSCLC I + II stage tumor tissues was lower than in NSCLC III stage tumor tissues (p = 0.017; Fig. 1c). Here, SPHK2 is linked to neoplasm.