Consistent with the finding in cervical squamous cell carcinoma, our study10 shows that the level of C1QBP in the renal carcinoma tissues is significantly lower than that in the adjacent normal tissues, and the expression of C1QBP could be used as an independent prognostic maker for cancer progression in the renal cell carcinoma (RCC) patients. The gene discussed is C1QBP; the disease is renal cell carcinoma.