These 19 genes included 13 genes at 4 loci found significantly associated with asthma in previous GWAS (2q12, 5q31, 9p24.1, 17q12-q21)4, 6, and six genes at six distinct loci that are novel: CRMP1 (4p16.1), ZNF192 (6p22.1), RAET1E (6q24.3), CTSL1 (9p21.33), C12orf43 (12q24.31) and JAK3 (19p13-p12). The gene discussed is JAK3; the disease is asthma.