NPHS2 and familial nephrotic syndrome: In recent years, abnormalities in a growing number of genes essential for podocyte development, structure and function have been identified in patients with congenital nephrotic syndrome (CNS) and SRNS, including podocin (NPHS2) and nephrin (NPHS1) and the advent of next generation sequencing will soon allow us to routinely screen all genes associated with SRNS [78].