PROS1 and hyperinsulinemic hypoglycemia, familial, 4: When a workup for thrombophilia is performed on nephrotic patients with thromboembolic complications, coexisting genetic prothrombotic conditions (protein S deficiency, Antithrombin III (ATIII) deficiency, factor V Leiden, hyperhomocysteinemia and the presence of antiphospholipid antibodies) are frequently identified, suggesting the importance of this type of screening [52, 57].