In insulin-gastrin (InsGas) mice that overexpress pancreatic gastrin to study gastric cancer, SHH, GLI1, but not GLI3 expression in pre-metaplastic lesions of non-infected mice was considerably reduced compared to normal adjacent glands, but partially re-expressed in H. felis-induced gastric metaplasia. This evidence concerns the gene GAST and Gastric Metaplasia.