IARS1 and cancer: Comparisons were repeated in the matched patient panel (Table 3) and overexpression of nuclear receptors in BRCA1mut as compared to sporadic cancer cases could be reproduced in terms of VDR (BRCA1mut vs. sporadic: IRS 6.00 vs. IRS 3.50 p = 0.008) as well as PPARγ (BRCA1mut vs. sporadic: IRS 6.00 vs. IRS 4.00, p = 0.008).