Using bivariate logistic regression analysis controlling for age, sex, co-infection (HIV-1 status and bacteremia), sickle cell trait (HbAS) and G6PD deficiency [26, 28–30], we determined the association between carriages of the FcγRIIA-131/FcγRIIIA-176/FcγRIIIB haplotypic structures and severe malaria anemia (SMA; Hb < 6.0 g/dL and any density parasitemia). This evidence concerns the gene GSTM1 and G6PD deficiency.