GSTM1 and infectious disease: Based on the observations that Fc gamma receptors (FcγRs) are important contributory factors for infectious disease immuno-pathogenesis, the association between the FcγRIIA-131Arg/His, FcγRIIIA-176F/V and FcγRIIIB-NA1/NA2 polymorphisms and pediatric severe malaria anemia (SMA; Hb < 6.0 g/dL, any density parasitemia) was determined.