FCGR3A and malaria: Although the exact mechanisms through which the FcγRIIA-131Arg/FcγRIIIA-176F/FcγRIIIBNA2 haplotype result in severe malaria susceptibility were not evaluated in the current study, it is scientifically plausible to propose that carriage of the haplotype may lead to a reduced crosslinking in neutrophils, hence low phagocytic activity resulting in reduced antibody dependent respiratory burst (ADRB), a mechanism by which neutrophils provide protection against clinical malaria [44–46].