However, it is worth noting that FcγRIIIA binding of IgG is important in induction of natural killer (NK) cells stimulatory properties which results in release of pro-inflammatory mediators, such as IL-1β, interferon-γ and tumor necrosis factor-α [50] whose imbalances have been implicated in pathogenesis of clinical malaria in children. This evidence concerns the gene IL1B and malaria.