IRF8, TMEM39A and IKZF3-ZPBP2 were previously identified as susceptibility loci for SLE in the multiracial replication study [4], Besides, ORMDL3 and GSDMB were found to have susceptibility loci for autoimmune diseases [16, 17]. The gene discussed is IKZF3; the disease is systemic lupus erythematosus.