IRF8 and systemic lupus erythematosus: Recently, multiethnic approach was utilized to find that three SLE risk loci exceeded the genome-wide significance threshold, including interferon regulatory factor 8 (IRF8), transmembrane protein 39A (TMEM39A), and 17q21 between IKAROS family of zinc finger 3 (IKZF3) and zona pellucida binding protein 2 (ZPBP2) [4].