LEP and obesity due to melanocortin 4 receptor deficiency: In these leptin-target tissues, we focused on resident perivascular cells (pericytes) that wrap around the tissue microvasculature (i.e., sinusoids/capillaries, small post-capillary venules), because they are vital for tissue health and regulate a variety of responses that are often defective in obesity, such as blood flow within tissues, vascular permeability, and local wound healing responses, including inflammation, angiogenesis, matrix remodeling and tissue regeneration [10].