Dysregulation of any of these candidates may affect crucial brain processes since many of them interact with genes already included in our original seed list for autism (APP, CYP19A1, ESR1, MAPK1, SETD2, SHANK2, TRPV1), some of them being highly interconnected nodes within the network (ESR1, APP, MAPK1). The gene discussed is CYP19A1; the disease is autism.