In addition, some of the most connected nodes within the network (ESR1, TP53, AKT1, MAPK1, Pkcs, EGFR and APP) may support molecular mechanisms implicated in neuronal connectivity and synaptic plasticity; dysfunction in these neurological pathways have been linked to social and anxiety-related behaviors, mood conditions, cognitive degeneration and loss of neurological function, characteristic features observed in many neurological conditions, including ASD [78–90]. This evidence concerns the gene ESR1 and Anxiety.