According to the results of previous studies, USP22 can induce EMT by regulating TGF-β1 in lung cancer cells [8], and elevated USP22 expression can promote EMT by up-regulating ZEB1 and Snail in pancreatic cancer cells though a process that involves focal adhesion kinase (FAK) signaling [29]. Here, USP22 is linked to familial pancreatic carcinoma.