CASP1 and dry eye syndrome: For NLRP3 inflammasome activation, the expression of IL-1β, IL-18, the NLRP3 inflammasome and ACS as well as caspase-1 separated from pro-caspase-1 in KCs isolated from mice in the Iturin A group were significantly lower than in KCs from the HFD group (Figure 4E and 4F).