HIF1A and lung cancer: Previously, it was reported that CUR suppressed lung cancer progression in C57BL/6 mice bearing xenografted cells via increase of the HIF1α/mTOR/VEGF/VEGFR cascade [49] and was effective in treating lung cancer by regulating oncogenes such as p53, enzymes such as LOX, transcription factors such as STAT-3 and protein kinases such as MAPK [50].