ALK and adenocarcinoma: Certain patients (e.g., those with adenocarcinoma histology, EGFR wild type, non/light-smokers, younger age) have rates of ALK rearrangements that approach 30%, and this group could benefit from the use of ALK-inhibitor treatment with crizotinib, a small molecule, multi-targeted tyrosine kinase inhibitor (TKI) [6].