To verify that the TSC2 status of the lymphomas does not affect the response of the cells to DHX9 suppression, we generated isogenic cell lines where TSC2 was suppressed via shRNA in either p53−/−Eμ-Myc lymphomas or Arf−/−Eμ-Myc lymphomas (which harbor functional p53). Here, TSC2 is linked to lymphoma.