Importantly, the FTC-133 cells transfected with the ST8SIA4 expression vector reversed the tumour growth induced by miR-146a/b in vivo, whereas the FTC-238 cells transfected with the ST8SIA4-specific shRNA reversed the tumour growth inhibitory effect of miR-146a/b inhibition in vivo (Figure 5E, Supplementary Figure 1C). This evidence concerns the gene ST8SIA4 and neoplasm.