Notably, lung cancer cell lines, A549 (non-metastatic) and NCI-H292 (metastatic), express substantial endogenous levels of TLR3 mRNA when not treated with polyI:C (Figure 1A, NT white bars) but they express low levels of TLR3 protein (Figure 1B and Supplementary Figure 1B) compared to those of NCI-H358 and NCI-H1299. This evidence concerns the gene TLR3 and lung cancer.