In lung adenocarcinoma cell lines NCI-H1975 and SK-LC-5, NKX2-1, a homeodomain transcription factor, has been shown to directly induce the expression of ROR1, which in turn sustains a favorable balance between prosurvival PI3K-AKT and pro-apoptotic p38 signaling [24]. This evidence concerns the gene PIK3CA and lung adenocarcinoma.