As the important finding, elevated expressions of cyclooxygenase 2 (COX-2) cancers tend to home into the bone, and COX-2 expression is associated with a large tumor size, a high histological grade, a negative HR status, a high cell proliferation rate, high p53 expression, presence of HER-2 amplification, and poor survival [19]. This evidence concerns the gene ERBB2 and neoplasm.