For example, Pygo2 was found to possess the ability to directly bind to histone H3 trimethylated at lysine 4 (H3K4me3) [19], associate with histone-modifying enzymes and recruits them to recruit chromatin to facilitate H3K4 trimethylation and histone acetylation in breast cancer cells [20]. This evidence concerns the gene PYGO2 and breast cancer.