PYGO2 and brain glioma: To investigate the effect of Pygo2 expression on PTX-induced cell growth arrest in human brain glioma U-87MG and U251 cell lines, several groups of stably transfected cell lines were constructed by transfecting cells with recombinant expression plasmids encoding pHM6, pHM6-Pygo2, pHM6-Pygo2 shRNA and pHM6-scr shRNA.