TP53 and medulloblastoma: Here, the lowest IC50 concentrations of RITA were obtained against the DAOY medulloblastoma cell line, which harbors a TP53 mutation, and the HD-MB03 medulloblastoma cell line, harboring a non-functional SNP but otherwise wildtype TP53. RITA produced an anti-tumor effect in 3 of the 4 tested medulloblastoma cell lines, independent of their TP53 status.