TP53 and neoplasm: Enforced dn-p53 expression did not significantly influence the effect of RITA treatment, as measured by the IC50s (HD-MB03 vs HD-MB03 dn-p53, P = 0.07; ONS-76 vs ONS-76 dn-p53, P = 0.33), demonstrating that TP53 mutational status does not strongly impact the anti-tumor activity of RITA.