For example, patients with higher expression levels of BUB1 have worse OS prognoses than those with lower expression levels of BUB1 in 10 cancer types (ACC, HNSC, KICH, KIRC, KIRP, LGG, LUAD, PAAD, and SKCM), and worse DFS prognoses in nine cancer types (ACC, KIRC, KIRP, LGG, LIHC, LUAD, PAAD, SARC and UVM) (Figure 4A, log-rank test, unadjusted P-value < 0.05). This evidence concerns the gene BUB1 and cancer.