Many TF genes (such as E2F1, EZH2, FOXM1 and MYBL2) and protein kinase genes (such as PLK1, TTK, AURKA, AURKB, BUB1, MELK, NEK2, PBK and PKMYT1) are overexpressed in various cancers, and their overexpression is associated with poor clinical outcomes in cancer (Supplementary Figure 1). The gene discussed is MELK; the disease is cancer.