Although many of the identified genes such as E2F1, EZH2, FOXM1, PLK1, TTK, AURKA, AURKB, and BUB1 have been revealed to be dysregulated in various cancers by previous studies, many other genes such as PLP1, MYOM1, NKAPL, and USP2 were investigated in few cancer-related studies, and thus represent our novel findings. The gene discussed is BUB1; the disease is cancer.