Among the 103 genes that are consistently upregulated in at least 17 of the 18 cancer types, there are 11 protein kinase encoding genes including PLK1, TTK, AURKA, AURKB, BUB1, BUB1B, GSG2, MELK, NEK2, PBK, and PKMYT1. The gene discussed is BUB1; the disease is cancer.