Therefore, from this case, we can conclude that T-LGL leukemia patients with unique TCRɑβ, and phenotype variants of dual CD4-/CD8- may pursue an aggressive clinical course and for elderly patient that cannot sustain an intensive intravenous chemotherapy, a relatively moderate chemotherapy like metronomic regimen should be recommended. This evidence concerns the gene CD4 and T-cell large granular lymphocyte leukemia.