A vast majority of patients (80%-90%) with T-LGL leukemia showed a CD3+ CD4-CD8+ CD57+ CD56- CD28-,TCRαβphenotype [17], while CD4- CD8- usually accompanied with TCR γδ, but had a favorable survival of 85% at 3 years [18]. The gene discussed is CD28; the disease is T-cell large granular lymphocyte leukemia.