As shown in Figure 3, the expression measurements of the two genes were markedly affected by the PTEC, and the largest fold changes of gene expression levels of SFRP1 and ACTA2 in the simulated samples with 70% PTEC, compared with their expression levels in the corresponding tumor epithelial cells, were 1.26 and 1.10, respectively; while the largest fold changes dramatically increased to 1.60 and 1.24, when the PTEC in the simulated samples decreased to 30%. This evidence concerns the gene ACTA2 and neoplasm.