As shown in Figure 3, compared with their expression levels in the corresponding tumor epithelial cells, the largest fold changes of gene expression levels of LIMS2 and MYH11 in the simulated samples with 70% PTEC were 1.14 and 1.22, respectively; while the largest fold changes increased to 1.34 and 1.51 when the PTEC in the simulated samples decreased to 30%. Here, LIMS2 is linked to neoplasm.