While M2 is totally different, they are characterized by the expression of CD163, CD206, CD204 and arginase-1, secreting IL-10 and TGF-β, expressing VEGF (vascular endothelial growth factor) and promoting both the activation of tumor related regulatory T cells and matrix formation, all of which promote tumor progression [10–12]. Here, TGFB1 is linked to neoplasm.