CCND1 and plasma cell myeloma: In this respect, translocations into the 11q13 locus directly deregulate CCND1; 6p21 CCND3; and 4p16 (MMSET), 16q23 (MAF), and 20q12 (MAFB) indirectly deregulate CCND2. In contrast, the mechanistic basis for cyclin-D dysregulation in HRD myeloma is less clear [6].