SLC8A1 and plasma cell myeloma: This model is unique from prior TC models in that it uses additional secondary genes, e.g. SLC8A1 up-regulation in t(11;14) or DSG2 up-regulation in t(4;14) myeloma, incorporated into a support vector machine (SVM) classification model to determine optimal subgroups in a simultaneous rather than dichotomous step-wise fashion.