Gene expression data additionally support the hypothesis that DLEU1 plays in part a role in BL cell signaling by demonstrating that anti-inflammatory and anti-apoptotic response genes, STAT1, IRAK1, ATK1, IκBα, CCNG2 and Bcl-2 were activated whereas hematopoietic-associated and chromatin remodeling-associated genes were downregulated in DLEU1-KD BL in comparison to wild type BL cells. The gene discussed is BCL2; the disease is Burkitt lymphoma.