While this study sheds some light on at least one mechanism of chemoimmunotherapy resistance in BL, it will be important to investigate the role of other gene products found in the 13q14.3 region such as microRNA clusters, miR-15a/miR-16-1 [24, 30], and long non-coding RNA (lncRNA) gene, DLEU2 [24], and RFP2 and/or KCNRG [31]. Here, KCNRG is linked to Burkitt lymphoma.