MAPK8 and colonic neoplasm: For instance, researchers found that activated c-Jun N-terminal kinase 1 (JNK1) physically and functionally interacts with VDR and positively regulates VDR expression at transcriptional and translational level resulting in the increased 1,25(OH)2D-mediated inhibition of colon cancer cell proliferation (HT29 cell line) [67].