This may be a more widespread strategy since the PI3K-Akt signaling cascade is also targeted by other bacterial pathogens, including Chlamydia trachomatis, Chlamydia pneumonia, Coxiella burnettii and Mycobacterium tuberculosis, to delay or prevent apoptosis in infected cells [44–47]. Here, AKT1 is linked to chlamydia trachomatis infectious disease.