We also examined the gross morphology of embryos at E16.5 and found that some Ngly1−/−;Engase−/− embryos showed anemia (5/16 [31.25%], Fig 2I, left panel) while no Ngly1+/+;Engase−/− embryo showed this phenotype (0/20, Fig 2I, right panel). The gene discussed is NGLY1; the disease is anemia.