Yang et al. reported that in human glioblastoma multiforme cells, PKM2 translocates into nucleus upon epidermal growth factor (EGF) receptor activation, where it phosphorylates histone H3 at threonine 11 (H3T11), which is required for dissociation of histone deacetylase 3 (HDAC3) from the promoter regions of CCDN1(encoding cyclin D1) and MYC, leading to their activation, tumor cell proliferation, cell-cycle progression, and brain tumorigenesis [8]. This evidence concerns the gene HDAC3 and glioblastoma.