CCN4 and neoplasm: A previous study showed that WISP1 binds to αvβ3 integrin and causes the activation of the ASK1, JNK/p38, and AP-1 pathways, which upregulate ICAM-1 expression and promote the migration of human OSCC cells [15], and tumor-secreted WISP1 promotes angiogenesis through VEGF-A expression and increased angiogenesis-related tumor growth [16].