Any disruption in this relay by, for example, suppressing the levels of mNT or NAF-1 [4] or introducing a NAF-1 mutant that is unable to accept or donate its cluster to cancer cells [14], will therefore result in the over accumulation of labile iron in mitochondria and the subsequent over-accumulation of ROS (Fig 4; [4, 14]). The gene discussed is MNT; the disease is cancer.