These include NAF-1 (CISD2), a non-lysosomal calcium-activated protease Calpain-1 (CAPN1), that could be related to CAPN2, previously shown to bind NAF-1 [24], and a number of other proteins that are known to be involved in immune response (e.g., integrin-beta), cytoskeleton (e.g., filamin and mucin) and cancer (e.g., FAT tumor suppressor and UXT). This evidence concerns the gene CISD2 and cancer.