Suppression (shRNA) of mNT [mNT(-)] or NAF-1 [NAF-1(-)] expression in human epithelial breast cancer cells (MCF-7 or MDA-MB-231) resulted in the disruption of MMP, the over-accumulation of labile iron and ROS in mitochondria and the activation of autophagy [4]. The gene discussed is NAF1; the disease is breast carcinoma.