Based on the large difference between the number of transcripts altered in expression in NAF-1(-) and mNT(-) cells (Fig 5), it is possible that NAF-1 is also involved in mediating many other signals in cells and could even integrate mitochondrial function with these signals (Fig 6), whereas mNT may have a more limited function in cancer cells that is directly linked to Fe and Fe-S biogenesis/transport. Here, NAF1 is linked to cancer.