Various isoforms of Thbs4 were enriched in JICC and CICC (Fig 4C) and THBS4 protein was detected within ANO1+ ICC-MY and ICC-SMP in the colon and ANO1+ ICC-MY and ICC-DMP in the jejunum (Fig 4G). The gene discussed is ANO1; the disease is intrahepatic cholangiocarcinoma.