Comparative analysis of the expression profiles among ICC, SMC, and PDGFRα+ cells showed that ICC were indeed enriched in well-known ICC markers (Ano1, Kit, and Prkcq) as well as unknown, new genes (Thbs4, Elovl6, Gja1, Gpr133, Edn3, Hprt, and Etv1) (Fig 3A). This evidence concerns the gene EDN3 and intrahepatic cholangiocarcinoma.