The simple effects of eight SNPs indicated increased risks of more than one end point: rs2252641 (ZEB2-AC074093.1), and rs11984041 (HDAC9) predicted both CAD and cardiovascular death, rs3217992 (CDKN2BAS) and rs216172 (SMG6) were associated with CAD and fatal MI, rs10455872 (LPA), rs4977574 (CDKN2A), and rs2259816 (HNF1A) were associated with CAD and non-fatal MI, while rs2895811 (HHIPL1) was associated with both fatal MI and cardiovascular death. This evidence concerns the gene SMG6 and coronary artery disorder.