TCF21 and coronary artery disorder: Post-hoc analyses showed that when constructing a stress-sensitive GRS comprised of the four SNPs [rs12190287 (TCF21), rs2954029 (TRIB1), rs9319428 (FLT1), and rs7173743 (ADAMTS7)] found in this study to interact unfavorably with stress for CAD, fatal MI or cardiovascular death (i.e. end points which include mortality outcomes), there were significant interactions with stress for fatal MI (p = 0.009) and for cardiovascular death (p = 0.004) (Table B in S1 File).