Although TP53 showed increased expression (p-value = 1.55 × 10−11) and MYC was slightly decreased (p-value = 0.002) in lung cancer tumors compared to paired normal tissues, TP53 target genes showed decreased expression (Fig 2C), consistent with the frequent observation of mutations of TP53 in adenocarcinomas [28]. The gene discussed is TP53; the disease is adenocarcinoma.