By using of K562 cells as a reference (Table 4), we found that MICA gene expression in the five ovarian cancer cell lines was significantly lower than K562 cells, while MICB and ULBP2 expression levels were similar to that in K562 cells; there was increased expression of ULBP3 in HO8910, OVCAR3 and SKOV3 cell; Increased ULBP4 expression was observed in 3AO, A2780 and HO8910 cells, whereas ULBP1 showed a low expression in all ovarian cancer cells with undetectable ULBP1 in A2780, OVCAR3 and SKOV3 cells. The gene discussed is ULBP2; the disease is ovarian cancer.