Even for genes that were significant in MutSigCV, oncodomain hotspots are more sensitive as they identify those same genes as significant in more cancer types for which they are known to play a role like BRAF in STAD [132–134], GBM [135–137], and UCEC [138,139] and EGFR in COAD [111,112], STAD [140,141], and SKCM [142–144]. This evidence concerns the gene EGFR and cancer.