For example, protein kinases harbor somatic variants in 3,634/5,848 (62.1%) of the tumors analyzed in this study yet only 27 / 465 human genes mapping to the PKc (cd00180) domain model were considered significant by MutSigCV, 16 of which were significant in only the PAAD cancer type. This evidence concerns the gene PRRT2 and pancreatic adenocarcinoma.