KLHL31 and cancer: Overall, oncodomain hotspots find many new genes that display similar somatic variant patterns to other genes within the same domain family that are well-studied in cancer genomics including 83 novel kinases (cd00180), 52 novel growth factors (cd00054 & cd00053), 33 novel Ras family members (cd00882), 26 novel cadherins (cd00031), 88 novel immunoglobins (pfam00047), and 43 novel Kelch-like (KLHL) genes.