GRB2 and cancer: The Grb2 protein is among recognition domain proteins in human that attract the most interest (http://thebiogrid.org), mostly because of its implication in a large number of protein complexes and canonical cell surface receptor signalling pathways associated with normal cell growth, proliferation and differentiation, and whose component proteins are mutated in a number of cancers (www.proteinatlas.org; www.uniprot.org).