P16 is involved in premature senescence as a tumor suppressor,32 which is also involved in replicative senescence by the P16-RB pathway.33 Thus, we explored the role of β-Arrestin1 on telomere-related replicative senescence, and found that β-Arrestin1 regulated the senescence via the hTERT-telomerase-telomere axis. The gene discussed is RB1; the disease is neoplasm.