Other notable candidate genes with loss of H3K27me3 occupancy are ABCB9 (associated with type 2 diabetes [65]); Sts (associated with HF diet and ob/ob models of obesity and type 2 diabetes [66]); and Ucn2 (associated with heart failure patients [67]). This evidence concerns the gene ABCB9 and obesity due to melanocortin 4 receptor deficiency.