Increased occupancy of H3K4me3 was observed in the promoter regions of various genes associated with metabolic stress and cardiac dysfunction in the HF-diet group, including those known to be involved in mitochondrial injury (Atp5g3, [48]), autophagy (Ei24, [49]), experimental diabetes mellitus (H6pd, [50], Erol1b, [51]), percentage body fat (SLC11A2, [52]), oxidation of inflammatory lipid substrates (CYP4F, [53]), and hypertrophic cardiomyopathy and chronic heart failure (Trim63, [54]). The gene discussed is EI24; the disease is congestive heart failure.