Work by others revealed that miR-126 promoted angiogenesis by alleviating suppression of VEGF (vascular endothelial growth factor) and FGF-2 (fibroblast growth factor) signaling by Spred1 (Sprouty-related, EVH1 domain-containing protein 1) [23], while the influence of upregulated miR-126 in aneurysm formation is not yet clear. This evidence concerns the gene FGF2 and aneurysm.