A similar trend was observed when the plasma levels of IL-17, IL-1α, keratinocyte chemoattractant (KC) and IL-4 were analysed in the groups of sedentary vs. exercising HFD mice with TNBS colitis, as the initial rise in the plasma levels of these factors in the sedentary HFD mice with colitis was ameliorated by physical voluntary training. The gene discussed is IL4; the disease is colitis.