From a large yeast two-hybrid screen, using ATOX1 as bait, we identified several new human protein partners [57] and several of the confident hits are proteins with functions related to signaling and cancer (e.g., CPEB4 (cytoplasmic polyadenylation element binding protein 4) [58], DNMT1 (DNA methyl transferase 1), and PPM1A (protein phosphatase, Mg2+/Mn2+ dependent 1A) [59,60,61,62]). The gene discussed is PPM1A; the disease is cancer.