MDM2 and neuroblastoma: In agreement with our own work using CGM097 (Figure 2A), targeted disruption of the MDM2/p53 interaction by the small molecule MDM2 antagonists, such as nutlin-3 and RG7388, suppresses the proliferation of both chemoresistant and sensitive neuroblastoma cell lines with wild-type TP53 (Chen et al., 2015; Van Maerken et al., 2009, 2006).