Therapy with crizotinib has significant clinical activity in patients with non-small cell lung cancer (NSCLC), anaplastic large cell lymphoma (ALCL) and inflammatory myofibroblastic tumor (IMT) that harbor ALK rearrangements (Kwak et al., 2010; Mossé et al., 2013). The gene discussed is ALK; the disease is anaplastic large cell lymphoma.