ALK and non-small cell lung carcinoma: Crizotinib, ceritinib and alectinib have been approved by multiple health authorities to treat advanced NSCLC harboring ALK rearrangements, whereas PF06463922 is a next-generation ALK inhibitor with higher potency and selectivity and appears to be active against all known clinically acquired ALK mutations (Johnson et al., 2014; Zou et al., 2015).